The process of creating computer-usable knowledge bases (KB) is complex, lengthy and still poorly understood by most health care professionals. Thus, there is a clear need for intermediate courses which teach knowledge engineering (KE) concepts and methods for these professionals. Understanding better its steps and requirements, they will be able to interact more efficiently with expert system builders. We describe here a suite of 12 microcomputer programs developed expressly for the purpose of the practical teaching of the most common KE techniques and its applications in Medicine and Biology. This is a one-semester, 64-hour course ministered at graduate level at the Biomedical Engineering program; which addresses theoretically and practically the main methods used to develop decision-making tools. The participants are a mix of physicians, human biologists, nurses and biomedical engineers pursuing a Master's degree either in Medicine, Physiology or Biomedical Engineering. For each method, the students receive a small, easy-to-use microcomputer program which includes a worked-out example and several proposed exercises, based on real decision-making problems in Medicine, in the following areas: algorithm-based systems (programs TIREO and RISKMAM), binary and quantitative pattern classification (BINREC and CURVCLAS), Bayesian probability (BAYES) and fuzzy systems (FUZZY), tree-, net-, frame- and rule-based logic programming (DECTREE, SEMANET, FRAMES and EXPERTMD, respectively), adaptive logic (EXPERGEN) and connectionist systems (NEURONET). The programs are small programmable "shell" systems and have been designed in Turbo BASIC 1.0 (Borland), with a common user interface, for IBM/PC-compatible microcomputers. They are now available in the public domain. Although limited in time, the course has been able to provide the students with a working knowledge on the scope and methods of computer-based KE in the Health Sciences and has achieved a good success. The extensive practical work with programs and examples related to medical problems has improved the students' motivation and understanding of the basic methodological approaches.
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